Cellular mechanism of glutation peroxidase mimetic was similar as GPx. Defense mechanism toward oxidative stress was mediated by endogenous antioxidant enyzme (superoxide dismutase/SOD, catalase/CAT, and GPx). Oxidative stress was characterized by increasing of malondialdehyde (MDA), decreasing of glutathione peroxidase (GPx) enzyme, and abnormal otoacoustic emission value (refer). Oxidative stress which caused by increasing of free radical ROS/RNS in the organs of Corti, causing apoptosis and necrosis of cochlear hair cell. Medical Faculty of General Achmad Yani UniversityĪcoustic trauma, Ebselen, GPx, MDA, Otoacoustic emission, AbstractĮxcessive noise exposure may cause mechanical and metabolic (oxidative stress) to the inner ear structure (cochlea), resulting in acoustic trauma (TA).
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